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GIL, GERMAN ALEJANDRO

Independent researcher

Speciality
Biologia Celular y Molecular- Cancer
Scientific discipline
Biochemistry and Molecular Biology - Medical Sciences
Topic
Macrophages Induce Endocrine Resistance in Breast Cancer Cells
Workplace
CENTRO DE INVESTIGACIONES EN QUIMICA BIOLOGICA DE CORDOBA (CIQUIBIC, CONICET-UNC)
Dependencies
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Address:
AV. HAYA DE LA TORRE S/N, X5000HUA - Córdoba - Argentina
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Summary Information provided by the agent in SIGEVA
The Epithelial mesenchimal transition program depends on a series of intracellular signaling networks involving, among others ERK, MAPK, PI3K, and c-Fos. Previous to EMT, CD44low/CD24high cells correspond to the phenotype of the majority of cells found in breast carcinomas whereas a shift to CD44+/CD24- cells, promotes EMT and a profile associated with human breast cancer stem cells leading to the acquisition of mesenchymal qualities and an increased ability to form mammospheres and increased m... The Epithelial mesenchimal transition program depends on a series of intracellular signaling networks involving, among others ERK, MAPK, PI3K, and c-Fos. Previous to EMT, CD44low/CD24high cells correspond to the phenotype of the majority of cells found in breast carcinomas whereas a shift to CD44+/CD24- cells, promotes EMT and a profile associated with human breast cancer stem cells leading to the acquisition of mesenchymal qualities and an increased ability to form mammospheres and increased metastatic potential.We found, that the microenvironment formed by macrophages induces both EMT in breast cancer cells with a stem cell?like phenotype and overexpression of c-Fos. Furthermore, in cultures, this microenvironment induces proliferation, invasiveness, and migration of these breast cancer cells, even in presence of Tamoxifen.. Furthermore, In vivo, this microenvironment increases breast tumor growth when macrophages are co-injected with MCF-7 cells into immunocompromised mice and Tamoxifen resistance.
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Lines of Investigation

todas las lineas

Natural and exact sciences

  • Biological sciences
  • Biochemistry and molecular biology (same as 3.1.10)
Technological Capacities

6 - Biological sciences

6.1 - Medicine, Human Health

  • 6.1.2 - Clinical Research, Trials
  • 6.1.10 - Medical Research

6.2 - Biology/Biotechnology

  • 6.2.2 - Cellular and Molecular Biology
  • 6.2.4 - In vitro Testing, Trials
  • 6.2.6 - Molecular design
Key Words
tumor microenvironmentcancer de mamamicromedioambiente tumoralmacrofagos asociados a tumores TAMEMTTAM tumor associated macrophagesBreast Cancer
Education

1999 - 2004

DR EN CIENCIAS QUIMICAS

FACULTAD DE CIENCIAS QUIMICAS, UNIVERSIDAD NACIONAL DE CORDOBA

1995 - 1999

LIC EN BIOQUIMICA CLINICA

UNIVERSIDAD NACIONAL DE CORDOBA

HR Training
Director of:
DIEZ, MARCELA
Scholars

DIEZ, Marcela Scholars

Co-director of:
PERALTA, MARIA FLORENCIA
Scientific Research Career at CONICET
ZANIN, JUAN PABLO
Scholars

PERALTA, Maria Florencia Scientific Research Career at CONICET

ZANIN, Juan Pablo Scholars

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