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GIL, GERMAN ALEJANDRO

INVESTIGADOR INDEPENDIENTE

SPECIALITY:

Biologia Celular y Molecular- Cancer

Scientific discipline:

Bioquímica y Biología Molecular - Ciencias Médicas

Topic:

MACROFAGOS INDUCEN RESISTENCIA ENDOCRINA EN CELULAS DE TUMORES DE MAMA . Macrophages Induce Endocrine Resistance in Breast Cancer Cells

Workplace

CENTRO DE INVESTIGACIONES EN QUIMICA BIOLOGICA DE CORDOBA (CIQUIBIC, CONICET-UNC) Depends on
Address:
AV. HAYA DE LA TORRE S/N, X5000HUA - Córdoba - Argentina

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S&T Expertise*

The Epithelial mesenchimal transition program depends on a series of intracellular signaling networks involving, among others ERK, MAPK, PI3K, and c-Fos. Previous to EMT, CD44low/CD24high cells correspond to the phenotype of the majority of cells found in breast carcinomas whereas a shift to CD44+/CD24- cells, promotes EMT and a profile associated with human breast cancer stem cells leading to the acquisition of mesenchymal qualities and an increased ability to form mammospheres and increased metastatic potential.We found, that the microenvironment formed by macrophages induces both EMT in breast cancer cells with a stem cell?like phenotype and overexpression of c-Fos. Furthermore, in cultures, this microenvironment induces proliferation, invasiveness, and migration of these breast cancer cells, even in presence of Tamoxifen.. Furthermore, In vivo, this microenvironment increases breast tumor growth when macrophages are co-injected with MCF-7 cells into immunocompromised mice and Tamoxifen resistance. *Information provided by the agent in SIGEVA

Lines of Investigation

todas las lineas CIENCIAS NATURALES Y EXACTAS - Ciencias Biológicas - Bioquímica y Biología Molecular (ídem 3.1.10)

Technological Capacities

  • 6. Ciencias biológicas
    • 1. Medicina, Salud humana
      • 1.2. Investigaciones clínicas, ensayos
      • 1.10. Investigaciones médicas
    • 2. Biología / Biotecnología
      • 2.2. Biología celular y molecular
      • 2.4. Ensayos in vitro, experimentos
      • 2.6. Diseño molecular

Key Words

TAM tumor associated macrophagesmacrofagos asociados a tumores TAMtumor microenvironmentmicromedioambiente tumoralcancer de mamaEMTBreast Cancer

Education

1999 - 2004

DR EN CIENCIAS QUIMICAS

FACULTAD DE CIENCIAS QUIMICAS, UNIVERSIDAD NACIONAL DE CORDOBA

1995 - 1999

LIC EN BIOQUIMICA CLINICA

UNIVERSIDAD NACIONAL DE CORDOBA

1994 - 1999

LIC EN BIOQUIMICA CLINICA

UNIVERSIDAD NACIONAL DE CORDOBA


S&T HR Training

Director of
DIEZ, MARCELA
Scholars
Co-director of

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