1. CONICET
  2. CONICET Community
  3. SERGIO EDUARDO ALVAREZ
CONICET Community
ALVAREZ, SERGIO EDUARDO

Independent researcher

Speciality
Biología Celular y Molecular
Scientific discipline
Medical Sciences - Medical Sciences
Topic
MECHANISMS OF MELANOMA RESISTANCE TO VEMURAFENIB AND DEVELOPMENT OF NEW BRAF INHIBITORS
Workplace
INSTITUTO MULTIDISCIPLINARIO DE INVESTIGACIONES BIOLOGICAS DE SAN LUIS (IMIBIO-SL, CONICET-UNSL)
Dependencies
Show more information Show less information
Address:
AV. EJERCITO DE LOS ANDES 950, 5700 - San Luis - Argentina
Show map
Summary Information provided by the agent in SIGEVA
During the last 5 years I have acquired a lot of expertise in the field of melanoma, inflammation and sphingosine-1-phosphate (S1P), which resulted in the publication of several papers in the field. Also, working with Dr. Sarah Spiegel during almost six years was of great help to interact and establish fruitful collaborations with many investigators in Argentina and USA. Based on recently published studies and our preliminary results, we hypothesize that tumor associated macrophages (TAM) modul... During the last 5 years I have acquired a lot of expertise in the field of melanoma, inflammation and sphingosine-1-phosphate (S1P), which resulted in the publication of several papers in the field. Also, working with Dr. Sarah Spiegel during almost six years was of great help to interact and establish fruitful collaborations with many investigators in Argentina and USA. Based on recently published studies and our preliminary results, we hypothesize that tumor associated macrophages (TAM) modulate the resistance of melanoma to vemurafenib. In addition, we suggest that S1P is involved in the polarization of TAMs. To test our hypothesis, we use both cellular and molecular approaches and have extensive experience in a variety of methods, including western blot, QPCR, migration, invasion, proliferation, ELISA and cell culture among others
Show more Show less
Lines of Investigation

Cancer Inflamacion

Natural and exact sciences

  • Biological sciences
  • Biochemistry and molecular biology (same as 3.1.10)
Technological Capacities

6 - Biological sciences

6.1 - Medicine, Human Health

  • 6.1.3 - Cytology, Cancerology, Oncology

6.2 - Biology/Biotechnology

  • 6.2.2 - Cellular and Molecular Biology
  • 6.2.4 - In vitro Testing, Trials
Key Words
INFLAMACIONRESISTENCIA A VEMURAFENIBCANCERINFLAMMATIONVEMURAFENIB RESISTANCEMELANOMA
Education

2003 - 2009

Postdoctorado

VIRGINIA COMMONWEALTH UNIVERSITY

1997 - 2002

Doctor den Biologia Molecular

FACULTAD DE QUIMICA, BIOQUIMICA Y FARMACIA, UNIVERSIDAD NACIONAL DE SAN LUIS

1990 - 1997

Lic.en Biologia Molecular

FACULTAD DE QUIMICA, BIOQUIMICA Y FARMACIA, UNIVERSIDAD NACIONAL DE SAN LUIS

HR Training
Director of:
CAMPOS, LUDMILA ESTEFANIA
Scientific Research Career at CONICET
DELGADO MONS, JOHINNA ILEANA
Scholars

CAMPOS, Ludmila Estefania Scientific Research Career at CONICET

DELGADO MONS, Johinna Ileana Scholars

Loading section Science and Technology Production...
Loading section Services...
Contact
Send Message