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  3. SERGIO EDUARDO ALVAREZ
CONICET Community

ALVAREZ, SERGIO EDUARDO

Independent researcher

SPECIALITY:

Biología Celular y Molecular

Scientific discipline:

Medical Sciences - Medical Sciences

Topic:

MECHANISMS OF MELANOMA RESISTANCE TO VEMURAFENIB AND DEVELOPMENT OF NEW BRAF INHIBITORS

Workplace

INSTITUTO MULTIDISCIPLINARIO DE INVESTIGACIONES BIOLOGICAS DE SAN LUIS (IMIBIO-SL, CONICET-UNSL) Depends on
Address:
AV. EJERCITO DE LOS ANDES 950, 5700 - San Luis - Argentina

Contact:

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S&T Expertise*

During the last 5 years I have acquired a lot of expertise in the field of melanoma, inflammation and sphingosine-1-phosphate (S1P), which resulted in the publication of several papers in the field. Also, working with Dr. Sarah Spiegel during almost six years was of great help to interact and establish fruitful collaborations with many investigators in Argentina and USA. Based on recently published studies and our preliminary results, we hypothesize that tumor associated macrophages (TAM) modulate the resistance of melanoma to vemurafenib. In addition, we suggest that S1P is involved in the polarization of TAMs. To test our hypothesis, we use both cellular and molecular approaches and have extensive experience in a variety of methods, including western blot, QPCR, migration, invasion, proliferation, ELISA and cell culture among others *Information provided by the agent in SIGEVA

Lines of Investigation

Cancer Inflamacion Natural and exact sciences - Biological sciences - Cell biology, microbiology

Technological Capacities

  • 6. Biological sciences
    • 1. Medicine, Human Health
      • 1.3. Cytology, Cancerology, Oncology
    • 2. Biology/Biotechnology
      • 2.4. In vitro Testing, Trials
      • 2.2. Cellular and Molecular Biology

Key Words

CANCERINFLAMACIONRESISTENCIA A VEMURAFENIBINFLAMMATIONVEMURAFENIB RESISTANCEMELANOMA

Education

2003 - 2009

Postdoctorado

VIRGINIA COMMONWEALTH UNIVERSITY

1997 - 2002

Doctor den Biologia Molecular

FACULTAD DE QUIMICA, BIOQUIMICA Y FARMACIA, UNIVERSIDAD NACIONAL DE SAN LUIS

1990 - 1997

Lic.en Biologia Molecular

FACULTAD DE QUIMICA, BIOQUIMICA Y FARMACIA, UNIVERSIDAD NACIONAL DE SAN LUIS


S&T HR Training

Director of
CAMPOS, LUDMILA ESTEFANIA
Scientific Research Career at CONICET
DELGADO MONS, JOHINNA ILEANA
Scholars

Science and Technology Production

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