Science and Technology Production
Book Chapter
Authorship
Alan Talevi
;
RUIZ, MARIA ESPERANZA
Date
2021
Publishing House and Editing Place
Springer
Book
The ADME Encyclopedia. A Comprehensive Guide on Biopharmacy and Pharmacokinetics
(pp. 1-7)
Springer
Springer
ISBN
978-3-030-51519-5
Summary
Information provided by the agent in
SIGEVA
The Baker-Lonsdale model describes the drug release from spherical monolithic drug delivery devices, in which the active pharmaceutical ingredient is initially dispersed throughout an inert diffusion matrix. It was derived from prior work by Higuchi on finely dispersed drug particles in an ointment base (in fact, it has been referred by some authors as Higuchi, Baker, and Lonsdale model). Higuchi originally assumed a flat geometry (thin film, slab); however, he later adapted his model to spheri...
The Baker-Lonsdale model describes the drug release from spherical monolithic drug delivery devices, in which the active pharmaceutical ingredient is initially dispersed throughout an inert diffusion matrix. It was derived from prior work by Higuchi on finely dispersed drug particles in an ointment base (in fact, it has been referred by some authors as Higuchi, Baker, and Lonsdale model). Higuchi originally assumed a flat geometry (thin film, slab); however, he later adapted his model to spherical geometries, in a similar manner that Baker and Lonsdale did. In principle, the Baker-Lonsdale model is applied to homogeneous polymeric matrix systems (with no pores, fractures, or capillaries), through which transport occurs by dissolution of the permeating species in the polymer, and subsequent diffusion down a concentration gradient. In essence, the release kinetics are estimated by solving Fick?s laws with the appropriate boundary conditions.
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Key Words
HIGUCHIDRUG RELEASEDRUG DISSOLUTIONBAKER AND LONSDALE MODEL