Science and Technology Production
Article
Authorship
Federico S. Weill
;
Eliana M Cela
;
Alejandro Ferrari
;
PAZ, MARIELA LAURA
;
Juliana Leoni
;
Daniel H. González Maglio
Date
2011
Publishing House and Editing Place
TAYLOR & FRANCIS INC
Magazine
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(pp. 838-847)
TAYLOR & FRANCIS INC
Summary
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UV radiation (UVR) produces deleterious effects which may finally lead to carcinogenesis. These adverse effects include tissue inflammation, free radical formation with consequent oxidation of proteins and lipids, DNA damage and immune function suppression. The aim of this study was to evaluate the effects of UVR at the local and systemic levels following acute (4 consecutive days with 0.5 Minimal Erythema Dose) or chronic exposure (20 consecutive days with 0.25 Minimal Erythema Dose). Locally,...
UV radiation (UVR) produces deleterious effects which may finally lead to carcinogenesis. These adverse effects include tissue inflammation, free radical formation with consequent oxidation of proteins and lipids, DNA damage and immune function suppression. The aim of this study was to evaluate the effects of UVR at the local and systemic levels following acute (4 consecutive days with 0.5 Minimal Erythema Dose) or chronic exposure (20 consecutive days with 0.25 Minimal Erythema Dose). Locally, histological alterations and epidermal T cell populations were studied. Systemically, inguinal lymph node and spleen T cells were analyzed with respect to proliferative response and cytokine production against a non-specific mitogen. Lymph node T cell populations were also characterized. Our results indicated that while both acute or chronic UVR produced epidermal hyperplasia and a decrease in epidermal T cell density, acute UVR increased T cell proliferative response, while chronic UVR produced the opposite effect, shifting the cytokine production towards a Th2/Treg profile. Therefore, even though acute irradiation produced a direct effect on skin, it did not correlate with a marked modification of overall T cell response , which is in contrast to marked effects in chronically irradiated animals. These findings may contribute to understanding the clinical relevance of occupational UVR exposure, typically related to outdoor activities which is associated with non-melanoma skin carcinogenesis.
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Key Words
UV Exposureacute irradiationchronic irradiationPeripheral T Cells