Science and Technology Production
Article
Authorship
Ponce Ponte, Micaela
;
ALOISIO, CAROLINA
;
Romero-Guerra, Diana Marcela
;
Gracia-Vásquez, Sandra
;
GARNERO, CLAUDIA
;
Longhi, Marcela Raquel
Date
2018
Publishing House and Editing Place
Future Medicine Ltd.
Magazine
Therapeutic Delivery,
vol. 9
(pp. 639-652)
- ISSN 2041-6008
Future Medicine Ltd.
Future Medicine Ltd.
ISSN
2041-6008
Summary
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SIGEVA
Binary and ternary complexes with hydroxypropyl-?-cyclodextrin (HP?CD), using glutamic acid (GA), proline (PRO) or lysine (LIS) as the third component, where developed to increase the solubility and the dissolution rate of norfloxacin (NOR). Methods/results: Complexation was evaluated by phase solubility studies, obtaining the highest NOR solubility with GA and HP?CD. Thermal analysis suggested that different kinds of interactions occur among NOR, HP?CD and each aminoacid (AA) , and when the sy...
Binary and ternary complexes with hydroxypropyl-?-cyclodextrin (HP?CD), using glutamic acid (GA), proline (PRO) or lysine (LIS) as the third component, where developed to increase the solubility and the dissolution rate of norfloxacin (NOR). Methods/results: Complexation was evaluated by phase solubility studies, obtaining the highest NOR solubility with GA and HP?CD. Thermal analysis suggested that different kinds of interactions occur among NOR, HP?CD and each aminoacid (AA) , and when the systems were prepared by kneading or by means of lyophilization. Dissolution studies, performed on simulated gastric fluid and subsequent simulated intestinal fluid, showed the highest rate of NOR from NOR:HPßCD:GA. Conclussion: NOR:HPßCD:GA was the best approach for improving the bioavailability of NOR.KEYWORDS: norfloxacin; hydroxypropyl-?-cyclodextrin; glutamic acid ; proline; lysine; solubility; dissolution rate; Nuclear magnetic resonance; thermal analysis.
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Key Words
HYDROXYPROPYL-B-CYCLODEXTRINSOLUBILITYNORFLOXACINLYSINETHERMAL ANALYSISPROLINENUCLEAR MAGNETIC RESONANCEGLUTAMINC ACIDDISSOLUTION RATE
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