Science and Technology Production
Article
Authorship
L. Squiquera
;
Daniel H. González Maglio
;
L. Gelmi
;
PAZ, MARIELA LAURA
;
M. FRIDMANIS
;
Juanita Bustamante
;
Juliana Leoni
Date
2001
Publishing House and Editing Place
Sociedad Argentina de Dermatología
Magazine
Revista Argentina de Dermatología,
vol. 82
(pp. 218-227)
- ISSN 1851-300X
Sociedad Argentina de Dermatología
Sociedad Argentina de Dermatología
ISSN
1851-300X
Summary
Information provided by the agent in
SIGEVA
Apoptosis or programmed cell death is a complex mechanism by which cells that have suffered genetic damage are eliminated. We have developed a cancer model induced byUVBin Hairless mice. In our model, the animals developed lesions with histologic diagnosis of squamous cell carcinoma after 4 months with suberitematogenous doses of UVB irradiation. The early effects of radiation was evaluated by irradiating the animals with a minimal erytematogenous dose. Skin biopsies were obtained from the dors...
Apoptosis or programmed cell death is a complex mechanism by which cells that have suffered genetic damage are eliminated. We have developed a cancer model induced byUVBin Hairless mice. In our model, the animals developed lesions with histologic diagnosis of squamous cell carcinoma after 4 months with suberitematogenous doses of UVB irradiation. The early effects of radiation was evaluated by irradiating the animals with a minimal erytematogenous dose. Skin biopsies were obtained from the dorsal skin and processed for routine H&E staining, and apoptosis (TUNEL). Seventy two hours post irradiation, a maximal tissular response consisting on hyperplasia and dysplasia such as suprabasal mitosis and loss of architecture. The TUNEL staining revealed scarce apoptotic cells in the epidermis and intense apoptosis in the dermal components such as mononuclear cells and fibroblast.
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Key Words
APOPTOSISIRRADIACION UVBRATONES HAIRLESSCARCINOGENESIS CUTANEA