Follicular helper T lymphocytes (TFH) in health and disease

Article

Authorship:

Parodi, Cecilia ; BADANO, MARIA NOEL ; Galassi, Nora Virginia ; Coraglia, Ana Carina ; BARE, PATRICIA ; Malbrán, Alejandro ; de Elizalde, Maria Marta

Date:

2014

Publishing House and Editing Place:

BaiShideng Publishing Group

Magazine:

World Journal of Hematology, vol. 4 (pp. 118-127) - ISSN 2218-6204
BaiShideng Publishing Group

ISSN:

2218-6204

Summary

A correct antibody response requires the participationof both B and T lymphocytes and antigen presentingcells. In this review we address the role of follicularhelper T lymphocytes (TFH) in this reaction. We shall focuson the regulation of their development and functionin health and disease. TFH can be characterized on thebasis of their phenotype and the pattern of secretionof cytokines. This fact is useful to study their participationin the generation of antibody deficiency in primaryimmunodeficiency diseases such as common variableimmunodeficiency, X-linked hyper IgM syndrome orX-linked lymphoproliferative disease. Increased numbersof TFH have been demonstrated in several autoimmunediseases and are thought to play a role in thedevelopment of autoantibodies. In chronic viral infectionscaused by the human immunodeficiency virus,hepatitis B or C virus, increased circulating TFH havebeen observed, but their role in the protective immuneresponse to these agents is under discussion. Likewise,an important role of TFH in the control of some experimentalprotozoan infections has been proposed, and itwill be important to assess their relevance in order todesign effective vaccination strategies.

Key Words

FOLLICULAR HELPER LYMPHOCYTESPROGRAMMED CELL DEATH-1 /PROGRAMMED CELL DEATH LIGAND 1 (PDL-1) OR PDL-2PROTOZOAN INFECTIONSINTERLEUKIN-21CHRONIC VIRAL INFECTIONSCHEMOKINE RECEPTOR 5AUTOIMMUNITYTFH DEVELOPMENTPRIMARY IMMUNODEFICIENCES

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