Solubility and release modulation effect of sulfamerazine ternary complexes with cyclodextrins and meglumine

Article

Authorship

ALOISIO, CAROLINA ; Oliveira, Anselmo Gomes de ; Longhi, Marcela Raquel

Date

2014

Publishing House and Editing Place

Elsevier Science

Magazine

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 100 (pp. 64-73) Elsevier Science

Summary Information provided by the agent in SIGEVA

This study investigated the effect on solubility and release of ternary complexes of sulfamerazine (SMR) with ?-(?CD), methyl-(M?CD) and hydroxypropyl-?-cyclodextrin (HP?CD) using meglumine (MEG) as the ternary component. The combination of MEG with M?CD resulted the best approach, with an increased effect (29-fold) of the aqueous solubility of SMR. The mode of inclusion was supported by 2D NMR, which indicated that real ternary complexes were formed between SMR, MEG and M?CD or HP?CD. Solid st... This study investigated the effect on solubility and release of ternary complexes of sulfamerazine (SMR) with ?-(?CD), methyl-(M?CD) and hydroxypropyl-?-cyclodextrin (HP?CD) using meglumine (MEG) as the ternary component. The combination of MEG with M?CD resulted the best approach, with an increased effect (29-fold) of the aqueous solubility of SMR. The mode of inclusion was supported by 2D NMR, which indicated that real ternary complexes were formed between SMR, MEG and M?CD or HP?CD. Solid state analysis was performed using Fourier-transform infrared spectroscopy (FT IR), differential scanning calorimetry (DSC) and powder X-ray diffraction (XRD), which demonstrated that different interactions occurred among SMR, MEG and M?CD or HP?CD in the ternary lyophilized systems. The ternary complexes with ?CD and M?CD produced an additional retention effect on the release of SMR compared to the corresponding binary complexes, implying that they were clearly superior in terms of solubility and release modulation.