Science and Technology Production
Colloidal properties of amiodarone in water at low concentration,
Article
Authorship:
BENEDINI, LUCIANO ALEJANDRO ; Santiago D. Palma, Erica P. Schulz, Marisa A. Frechero, Pablo C. SchulzDate:
2010Publishing House and Editing Place:
ACADEMIC PRESS INC ELSEVIER SCIENCEMagazine:
JOURNAL OF COLLOID AND INTERFACE SCIENCE, vol. 342 (pp. 407-414) ACADEMIC PRESS INC ELSEVIER SCIENCESummary *
ABSTRACT Amiodarone aqueous systems at concentrations C £ 3 mg/mL were studied with different techniques (conductivity, solubility, ion-selective electrodes, pH, viscosity, polarizing microscopy, computational simulation, electron microscopy and fluorescence at various temperatures. The Krafft point (TK = 70.6 ºC) was determined. A partial phase diagram was plotted showing the critical micelle concentration (CMC) dependence on temperature, the solubility and a transition between a coacervate and an unstable gel below TK as a function of temperature. The nature of aggregates below TK phase diagram was plotted showing the critical micelle concentration (CMC) dependence on temperature, the solubility and a transition between a coacervate and an unstable gel below TK as a function of temperature. The nature of aggregates below TK different techniques (conductivity, solubility, ion-selective electrodes, pH, viscosity, polarizing microscopy, computational simulation, electron microscopy and fluorescence at various temperatures. The Krafft point (TK = 70.6 ºC) was determined. A partial phase diagram was plotted showing the critical micelle concentration (CMC) dependence on temperature, the solubility and a transition between a coacervate and an unstable gel below TK as a function of temperature. The nature of aggregates below TK phase diagram was plotted showing the critical micelle concentration (CMC) dependence on temperature, the solubility and a transition between a coacervate and an unstable gel below TK as a function of temperature. The nature of aggregates below TK £ 3 mg/mL were studied with different techniques (conductivity, solubility, ion-selective electrodes, pH, viscosity, polarizing microscopy, computational simulation, electron microscopy and fluorescence at various temperatures. The Krafft point (TK = 70.6 ºC) was determined. A partial phase diagram was plotted showing the critical micelle concentration (CMC) dependence on temperature, the solubility and a transition between a coacervate and an unstable gel below TK as a function of temperature. The nature of aggregates below TK phase diagram was plotted showing the critical micelle concentration (CMC) dependence on temperature, the solubility and a transition between a coacervate and an unstable gel below TK as a function of temperature. The nature of aggregates below TK K = 70.6 ºC) was determined. A partial phase diagram was plotted showing the critical micelle concentration (CMC) dependence on temperature, the solubility and a transition between a coacervate and an unstable gel below TK as a function of temperature. The nature of aggregates below TKK as a function of temperature. The nature of aggregates below TK at different concentrations was determined. Micellization is an entropy-driven process which is probably caused by a strong dehydration of the amiodarone backbone on micellization. CMC, micelle aggregation number and TK given in earlier literature were misinterpreted in the original articles and are re-interpreted in this work. misinterpreted in the original articles and are re-interpreted in this work. K given in earlier literature were misinterpreted in the original articles and are re-interpreted in this work. Information provided by the agent in SIGEVAKey Words
GELKRAFFT POINTCRITICAL MICELLE CONCENTRATIONHYDRATIONAMIODARONACOACERVATE