Science and Technology Production
Article
Authorship
Aguilera, Jordi
;
MOGLIONI, ALBERTINA GLADYS
;
Mor, Àlex
;
Ospina, Jimena
;
Illa, Ona
;
Ortuño, Rosa M.
Date
2014
Publishing House and Editing Place
Elsevier
Magazine
TETRAHEDRON,
vol. 70
(pp. 6546-6553)
Elsevier
Summary
Information provided by the agent in
SIGEVA
Divergent and versatile synthetic routes leading to the title compounds are described. They start from a common chiral precursor derived from (?)-(S)-verbenone and afford polyfunctional ?-lactams and ?- and ?-amino acids. The cyclobutane moiety in these molecules acts as a chiral and polyfunctional platform providing stereogenic centres with unambiguous absolute configuration that control the chirality of the newly produced asymmetric carbons. Furthermore, it affords functional groups and carbo...
Divergent and versatile synthetic routes leading to the title compounds are described. They start from a common chiral precursor derived from (?)-(S)-verbenone and afford polyfunctional ?-lactams and ?- and ?-amino acids. The cyclobutane moiety in these molecules acts as a chiral and polyfunctional platform providing stereogenic centres with unambiguous absolute configuration that control the chirality of the newly produced asymmetric carbons. Furthermore, it affords functional groups and carbon chains suitable not only to create the basic skeleton of the desired products but additional functional groups. These features confer on these derivatives a great versatility for further uses in the development of new drugs and as synthetic building blocks.
Show more
Show less
Key Words
VerbenoneChiralityAmino acidsPolyfunctional scaffolds?-LactamsDivergent synthesisBuilding blocks
Download or request the full text