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In Vitro Antiplasmodial Activity of Sesquiterpene Lactones from
Article
Authorship:
Sulsen V ; Gutierrez Yapu D ; LAURELLA, LAURA CECILIA ; Anesini C ; Gimenez Turba A ; Martino V ; Muschietti LDate:
2011Publishing House and Editing Place:
OXFORD UNIV PRESSMagazine:
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, vol. 2011 (pp. 1-4) OXFORD UNIV PRESSSummary *
The in vitro antiplasmodial activity of Ambrosia tenuifolia organic extract and its isolated sesquiterpene lactones, psilostachyin and peruvin, has been evaluated against Plasmodium falciparum F32 and W2 strains. The cytotoxicity of both compounds was determined on lymphoid cells, and their corresponding selectivity indexes (SIs) were calculated. Peruvin was the most active compound on F32 strain of P. falciparum with a 50% inhibitory concentration value (IC50) of 0.3ug/mL (1.1 uM) whereas psilostachyin showed activity on both strains (IC50 = 0.6 (2.1 uM) and 1.8 ug/mL (6.4 uM)). Fifty percent cytotoxic concentration (CC50) values (48 h) were 6.8 ug/mL (24.3 uM) and 10.0 ug/mL (37.9 uM) for psilostachyin and peruvin, respectively. Information provided by the agent in SIGEVAKey Words
Ambrosia tenuifoliasesquiterpene lactones Antiplasmodial activity