Science and Technology Production
Congress
Authorship
Clement Florencia
;
Venara Marcela
;
Maglio Silvana
;
MARTIN, AYELEN
;
Mathó Cecilia
;
Petre Cesar
;
García Lombardi Mercedes
;
Bergadá Ignacio
;
Pennisi Patricia
Date
2015
Publishing House and Editing Place
The Endocrine Society
Summary
Information provided by the agent in
SIGEVA
Background: Central nervous system (CNS) tumors are the most frequent solid tumors in the pediatric population. Histologic grading is a mean of predicting the biological behavior of these tumors and survival is strongly correlated with tumor gradation. The insulin-like growth factor (IGF) system of ligands and receptors are known to play an important role in both normal and neoplastic growth. Recently, nuclear translocation of the type 1 insulin growth factor receptor (IGF-1R) has been demonstr...
Background: Central nervous system (CNS) tumors are the most frequent solid tumors in the pediatric population. Histologic grading is a mean of predicting the biological behavior of these tumors and survival is strongly correlated with tumor gradation. The insulin-like growth factor (IGF) system of ligands and receptors are known to play an important role in both normal and neoplastic growth. Recently, nuclear translocation of the type 1 insulin growth factor receptor (IGF-1R) has been demonstrated in tumor tissues. Although the IGF-1R expression has been described in CNS pediatric tumors, information about the intracellular localization and correlation with tumor grade is lacking. Objective: To characterize the expression and intracellular localization of the IGF-1R CNS tumors from pediatric patients according to WHO 2007 grading. Patients and Methods: Thirty four patients (19 males/15 females), median aged 7.9 yrs, (range 0.9-18.3), with CNS tumors without previous medical treatment were included (23 gliomas, 5 medulloblastomas, 6 ependimomas). Formalin-fixed 5µm tumor tissue sections were immunostained for IGF-1Rβ. IGF-1R expression and intracellular localization were scored as positive or negative, nuclear or cytoplasmic respectively. Contingency tables were analyzed using Pearson´s χ2 test to assess relationships between IGF-1R and tumor grade (Low grade I-II; High grade III-IV). Results: IGF-1R staining was positive in 15/20 (75%) low grade tumors and in 14/14 (100%) high grade tumours (χ2 Test:p<0.05). Low grade tumors showed cytoplasmic localization of IGF-1R in 13/15 cases, while in high grade tumours IGF-1R localization was nuclear in 3/14 (χ2 Test:p
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Key Words
SNCIGF-1RGliomas