Science and Technology Production
Congress
Authorship
Ana Paula Nuñez
;
IPAR, EUGENIA
;
Gisella M. Centurion
;
Sebastian Verrastro
;
Armentano, Ricardo L
;
Cymberknop, Leandro J
Date
2025
Publishing House and Editing Place
Springer
Summary
Information provided by the agent in
SIGEVA
Early detection of subclinical vascular alterations is critical for effective cardiovascular risk stratification and prevention. Arterial stiffness (AS), a hallmark of vascular aging and hypertension, is a strong, independent predictor of cardiovascular morbidity and mortality. While carotid-femoral Pulse Wave Velocity (cfPWV) is the non-invasive gold standard for AS assessment, it requires skilled operators and involves some procedural risks (e.g. plaque disturbance), limiting its broader clin...
Early detection of subclinical vascular alterations is critical for effective cardiovascular risk stratification and prevention. Arterial stiffness (AS), a hallmark of vascular aging and hypertension, is a strong, independent predictor of cardiovascular morbidity and mortality. While carotid-femoral Pulse Wave Velocity (cfPWV) is the non-invasive gold standard for AS assessment, it requires skilled operators and involves some procedural risks (e.g. plaque disturbance), limiting its broader clinical and ambulatory application. Optical timing-based approaches offer safer and more practical alternatives. This study presents a comprehensive evaluation of Pulse Arrival Time (PAT) at five peripheral arterial sites—carotid, temporal, radial, digital, and tibial—to explore their potential for non-invasive vascular assessment of AS using photoplethysmography waveforms (PPGW). Three complementary aims are addressed: assessing the feasibility of acquiring PAT at these sites using PPGW, conducting an in-vivo study to assess the reliability of using PPGW and electrocardiographic (ECG) signals acquired from a demographically diverse cohort, and comparing obtained values and estimating age-related changes in estimated PAT from a validated in-silico database. The temporal arterial consistently demonstrated favorable characteristics, including high-quality signals and clear associations with age and disease status. These findings position the temporal site as a particularly favorable candidate for the development of non-invasive diagnostic tools for early vascular aging detection, broader cardiovascular risk screening, and the expansion of the cerebrovascular assessment frontier.
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Key Words
PULSE WAVE VELOCITYARTERIAL STIFFNESSPHOTOPLETHYSMOGRAPHYPULSE ARRIVAL TIMECARDIOVASCULAR HEALTH