Science and Technology Production
Book Chapter
Authorship
GARNERO, CLAUDIA
;
ZOPPI, ARIANA
;
ALOISIO, CAROLINA
;
Longhi, Marcela Raquel
Date
2017
Publishing House and Editing Place
Elsevier
Book
Nanoscale fabrication, optimization, scale-up and biological aspects of pharmaceutical nanotechnology
(pp. 253-299)
Elsevier
Elsevier
ISBN
978-0-12-813629-4
Summary
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SIGEVA
A large number of drugs of therapeutic interest presents inappropriate physico-chemical properties (e.g. low dissolution rate, solubility, or permeability in biological fluids) that result in formulations with low bioavailability and large inter-subject variability, producing therapeutic problems related to therapeutic effectiveness. Thus, one of the greatest challenges for the pharmaceutical field today is the application of technological formulations as strategies to enhance their bioavailabi...
A large number of drugs of therapeutic interest presents inappropriate physico-chemical properties (e.g. low dissolution rate, solubility, or permeability in biological fluids) that result in formulations with low bioavailability and large inter-subject variability, producing therapeutic problems related to therapeutic effectiveness. Thus, one of the greatest challenges for the pharmaceutical field today is the application of technological formulations as strategies to enhance their bioavailability. This chapter focuses on the design of systems with promising properties based on the intermolecular interactions of the components, considering the formulation and manufacturing techniques of the delivery systems, as well as the factors that may affect the drug and the pharmaceutical form. Specifically, we will describe the crucial role of the innovative systems, including binary and multicomponent complexes with cyclodextrins, microemulsions, solid self-microemulsifying drug delivery systems and solid lipid nanoparticles. We will highlight the feasibility of these to improve biopharmaceutical properties.
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Key Words
DRUG DELIVERY SYSTEMSBINARY CYCLODEXTRIN COMPLEXESMULTICOMPONENT COMPLEXESMICROEMULSIONSDISSOLUTION RATESOLID SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEMSSOLID LIPID NANOPARTICLESSOLUBILITYPERMEABILITYBIOAVAILABILITY
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