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6-Bromo-3'-nitroflavone, a new high affinity benzodiazepine receptor agonist, recognizes two populations of cerebral cortical binding sites.

Article

Authorship
MARDER, NORA MARIEL
Date
1997
Magazine
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 7 (pp. 373-378)
Summary Information provided by the agent in SIGEVA
The synthesis and biochemical characterization of 6-bromo-3’-nitroflavone (1) is presented. Compound 1 has higher affinity for cerebellar and cerebral cortical than for striatal, hippocampal, or spinal cord benzodiazepine receptors (BDZ-Rs). In the cerebral cortex it recognizes two populations of binding sites (Kis 1.2 nM and 15.5 nM, respectively), and at doses of 0.01 to 0.3 mg/kg, ip produces anxiolytic effects in mice.