Science and Technology Production
ELM—the Eukaryotic Linear Motif resource—2024 update
Article
Authorship:
Kumar, Manjeet ; Michael, Sushama ; Alvarado-Valverde, Jesús ; Zeke, András ; Lazar, Tamas ; Glavina, Juliana ; Nagy-Kanta, Eszter ; MAC DONAGH, JUAN ; Kalman, Zsofia E ; Pascarelli, Stefano ; Palopoli, Nicolas ; Dobson, László ; Suarez, Carmen Florencia ; Van Roey, Kim ; Krystkowiak, Izabella ; Griffin, Juan Esteban ; Nagpal, Anurag ; Bhardwaj, Rajesh ; Diella, Francesca ; Mészáros, Bálint ; Dean, Kellie ; Davey, Norman E ; Pancsa, Rita ; Chemes, Lucía B ; Gibson, Toby JDate:
2024Publishing House and Editing Place:
OXFORD UNIV PRESSMagazine:
NUCLEIC ACIDS RESEARCH, vol. 52 (pp. 442-455) OXFORD UNIV PRESSSummary *
Short Linear Motifs (SLiMs) are the smallest structural and functional components of modular eukaryotic proteins. They are also the most abundant, especially when considering post-translational modifications. As well as being found throughout the cell as part of regulatory processes,SLiMs are extensively mimicked by intracellular pathogens. At the heart of the Eukaryotic Linear Motif (ELM) Resource is a representative (notcomprehensive) database. The ELM entries are created by a growing community of skilled annotators and provide an introduction to linear motiffunctionality for biomedical researchers. The 2024 ELM update includes 346 novel motif instances in areas ranging from innate immunity to bothprotein and RNA degradation systems. In total, 39 classes of newly annotated motifs have been added, and another 17 existing entries havebeen updated in the database. The 2024 ELM release now includes 356 motif classes incorporating 4283 individual motif instances manuallycurated from 4274 scientific publications and including >700 links to experimentally determined 3D structures. In a recent development, theInterPro protein module resource now also includes ELM data. ELM is available at: http://elm.eu.org. Information provided by the agent in SIGEVAKey Words
Short Linear Motifs