Science and Technology Production
Article
Authorship
Date
2004
Publishing House and Editing Place
Elsevier
Magazine
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,
vol. 14
(pp. 133-136)
Elsevier
Summary
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SIGEVA
The antiproliferative activity of several natural flavonoids and a series of synthetic derivatives was evaluated in vitro against a cell line derived from a human cervical carcinoma (WISH cells). According to their activities, the most potent flavonoids were 2´-nitroflavone (14), 2´,6-dinitroflavone (15) and the n-butyl ester of caffeic acid (29). When these derivatives were tested in the presence of recombinant human interferon-a2b (rhIFN-a2b), a cytokine exhibiting an antimitogeni...
The antiproliferative activity of several natural flavonoids and a series of synthetic derivatives was evaluated in vitro against a cell line derived from a human cervical carcinoma (WISH cells). According to their activities, the most potent flavonoids were 2´-nitroflavone (14), 2´,6-dinitroflavone (15) and the n-butyl ester of caffeic acid (29). When these derivatives were tested in the presence of recombinant human interferon-a2b (rhIFN-a2b), a cytokine exhibiting an antimitogenic action on WISH cells, an additive effect on cell growth inhibition was observed. Time course studies of the antiproliferative action exerted by the active flavone derivatives or the rhIFN-a2b suggested that these compounds induced cell death.
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Key Words
SYNTHETIC FLAVONOIDSNATURAL FLAVONOIDSIFN-ALPHA2B