Science and Technology Production
Book Chapter
Authorship
TALEVI, ALAN
;
María E. Ruiz
Date
2022
Publishing House and Editing Place
Springer Nature
Book
The ADME Encyclopedia. A Comprehensive Guide on Biopharmacy and Pharmacokinetics
(pp. 519-523)
Springer Nature
Springer Nature
ISBN
978-3-030-51519-5
Summary
Information provided by the agent in
SIGEVA
The Higuchi equation is a mathematical model of drug release originally conceived to describe the release of a drug from a thin ointment film into the skin [1] (although it has been later applied to model drug release from other systems). Among other considerations, the model assumes that the initial drug concentration in the film is much higher than the solubility of the drug in the ointment base. Hence, drug release will encompass both drug dissolution and diffusion. Moreover, it is assumed t...
The Higuchi equation is a mathematical model of drug release originally conceived to describe the release of a drug from a thin ointment film into the skin [1] (although it has been later applied to model drug release from other systems). Among other considerations, the model assumes that the initial drug concentration in the film is much higher than the solubility of the drug in the ointment base. Hence, drug release will encompass both drug dissolution and diffusion. Moreover, it is assumed that the dissolution of the drug within the ointment base will be rapid in comparison with its diffusion.
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Key Words
HIGUCHIDRUG DELIVERYCONTROLLED DRUG RELEASEDRUG RELEASEDIFFUSIONHIGUCHI MODELDRUG DISSOLUTION