Endocrine effects of the GnRH antagonist, acyline, in domestic dogs

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Resumen *

GnRH antagonists may have a future in the control of canine reproductive functions. In this study, the effect of a single dose of the potent GnRH antagonist, acyline, on serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone (T) concentrations were evaluated in male dogs. Blood samples were drawn before (day -1) and after (30, 60 and 90 minutes, 3, 6, 9, 12 and 24 hours, and 3, 6, 9, 14, 22, and 29 days) acyline (330 ug/kg sc) injection for serum hormone determinations. Comparisons of time points were carried out by ANOVA for repeated measures. Follicle-stimulating hormone, LH, and T serum concentrations varied throughout the study period (P < 0.01, < 0.05, and < 0.01, respectively). Gonadotrophins decreased below pretreatment values 60 minutes after injection while T took 90 minutes to fall below baseline (P > 0.05). Follicle-stimulating hormone, LH and T decreased until Day 9 when they reached their nadir at 2.0 ±1.1 ng/ml [p< 0.01]; 1.2 ±0.2 ng/ml [p> 0.05], and 0.5 ±0.2 ng/ml [p< 0.05], respectively. Both gonadotrophins and T began increasing on Day 14 after injection, although FSH and T serum concentrations still remained below baseline on that Day (p > 0.05). Follicle-stimulating hormone and T rebounded above baseline on Day 29, while LH reached concentrations similar to baseline at this time point (p > 0.05). No local or systemic side effects have been detected in any animal following acyline administration. In dogs, a single acyline dose safely and reversibly decreased gonadotrophins and T for nine days after administration. Información suministrada por el agente en SIGEVA