1. CONICET
  2. Comunidad CONICET
  3. SERGIO EDUARDO ALVAREZ
Comunidad CONICET
ALVAREZ, SERGIO EDUARDO

Investigador independiente

Especialidad
Biología Celular y Molecular
Disciplina Científica
Ciencias Médicas - Ciencias Médicas
Tema
MECANISMOS DE RESISTENCIA DEL MELANOMA A VEMURAFENIB Y DESARROLLO DE NUEVOS INHIBIDORES DE BRAF
Lugar de Trabajo
INSTITUTO MULTIDISCIPLINARIO DE INVESTIGACIONES BIOLOGICAS DE SAN LUIS (IMIBIO-SL, CONICET-UNSL)
Depende de
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Dirección:
AV. EJERCITO DE LOS ANDES 950, 5700 - San Luis - Argentina
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Resumen Información suministrada por el agente en SIGEVA
During the last 5 years I have acquired a lot of expertise in the field of melanoma, inflammation and sphingosine-1-phosphate (S1P), which resulted in the publication of several papers in the field. Also, working with Dr. Sarah Spiegel during almost six years was of great help to interact and establish fruitful collaborations with many investigators in Argentina and USA. Based on recently published studies and our preliminary results, we hypothesize that tumor associated macrophages (TAM) modul... During the last 5 years I have acquired a lot of expertise in the field of melanoma, inflammation and sphingosine-1-phosphate (S1P), which resulted in the publication of several papers in the field. Also, working with Dr. Sarah Spiegel during almost six years was of great help to interact and establish fruitful collaborations with many investigators in Argentina and USA. Based on recently published studies and our preliminary results, we hypothesize that tumor associated macrophages (TAM) modulate the resistance of melanoma to vemurafenib. In addition, we suggest that S1P is involved in the polarization of TAMs. To test our hypothesis, we use both cellular and molecular approaches and have extensive experience in a variety of methods, including western blot, QPCR, migration, invasion, proliferation, ELISA and cell culture among others
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Líneas de Investigación

Cancer Inflamacion

Ciencias naturales y exactas

  • Ciencias biológicas
  • Bioquímica y biología molecular (ídem 3.1.10)
Capacidades Tecnológicas

6 - Ciencias biológicas

6.1 - Medicina, Salud humana

  • 6.1.3 - Citología, cancerología, oncología

6.2 - Biología / Biotecnología

  • 6.2.2 - Biología celular y molecular
  • 6.2.4 - Ensayos in vitro, experimentos
Palabras Clave
INFLAMACIONRESISTENCIA A VEMURAFENIBCANCERINFLAMMATIONVEMURAFENIB RESISTANCEMELANOMA
Formación Académica

2003 - 2009

Postdoctorado

VIRGINIA COMMONWEALTH UNIVERSITY

1997 - 2002

Doctor den Biologia Molecular

FACULTAD DE QUIMICA, BIOQUIMICA Y FARMACIA, UNIVERSIDAD NACIONAL DE SAN LUIS

1990 - 1997

Lic.en Biologia Molecular

FACULTAD DE QUIMICA, BIOQUIMICA Y FARMACIA, UNIVERSIDAD NACIONAL DE SAN LUIS

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