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NAZER, EZEQUIEL

INVESTIGADOR ASISTENTE

SPECIALITY:

Biología Molecular y Celular

Scientific discipline:

Bioquímica y Biología Molecular - Ciencias Médicas

Topic:

Estudio funcional y molecular de la proteína argonauta 1 (AGO1) en la activación de enhancers dependiente de estrógenos

Workplace

INSTITUTO DE FISIOLOGIA, BIOLOGIA MOLECULAR Y NEUROCIENCIAS (IFIBYNE, CONICET-UBA) Depends on
Address:
INTENDENTE GUIRALDES 2160, piso 2, C1428EGA - Capital Federal - Argentina

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S&T Expertise*

Breast cancer is the leading cause of cancer-related death in women. Positive outcomes can be attributed to success with targeting hormone receptors in hormone receptor-positive disease, however, a significant fraction develops resistance and progresses to metastatic disease. At the molecular level, perturbations of cell type-specific enhancers and their transcriptional programs play key roles in tumorigenesis. We have recently shown a non-canonical role for Argonaute1 (AGO1) as coactivator of estrogen-induced enhancers. ChIP-seq analysis showed that AGO1 colocalizes with estrogen-responsive enhancers in MCF7 cells (ER+ breast cancer cell line) in an estrogen-dependent manner. Interestingly, coimmunoprecipitation assays showed that AGO1 interacts with ER upon estradiol treatment. AGO1 modulates the recruitment of ER onto induced-enhancers, activates enhancer transcription, enhances induced enhancer-promoter interactions and activates target promoters in response to E2. Overall, these results suggest that AGO1 plays a critical role during the activation estrogen-induced enhancers. *Information provided by the agent in SIGEVA

Lines of Investigation

Regulación de la expresión génica CIENCIAS NATURALES Y EXACTAS - Ciencias Biológicas - Bioquímica y Biología Molecular (ídem 3.1.10)

Technological Capacities

  • 6. Ciencias biológicas
    • 2. Biología / Biotecnología
      • 2.2. Biología celular y molecular
    • 3. Investigación del genoma
      • 3.1. Bioinformática
      • 3.2. Expresión genética, investigación proteómica

Key Words

ChromatinCromatinaTranscriptionEnhancers Transcripción

Education

2006 - 2011

Doctor en Biología Molecular y Biotecnología

UNIVERSIDAD NACIONAL DE SAN MARTIN

1999 - 2004

Licenciado en Ciencias Biológicas

UNIVERSIDAD DE BUENOS AIRES


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